Cardiosphere‐Derived Cell Exosomes Modulate mdx Macrophage Phenotype and Alter Their Secretome
                    
                        
                            نویسندگان
                            
                            
                        
                        
                    
                    
                    چکیده
منابع مشابه
Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment
Prostate cancer (PCa) is the most frequently diagnosed cancer in men. Current research on tumour-related extracellular vesicles (EVs) suggests that exosomes play a significant role in paracrine signaling pathways, thus potentially influencing cancer progression via multiple mechanisms. In fact, during the last decade numerous studies have revealed the role of EVs in the progression of various p...
متن کاملAbstract Astrocytes Modulate Microglial Phenotype and Dendritic Cell-like Properties Astrocytes Modulate Microglial Phenotype and Dendritic Cell-like Properties Astrocytes Modulate Microglial Phenotype and Dendritic Cell-like Properties
ASTROCYTES MODULATE MICROGLIAL PHENOTYPE AND DENDRITIC CELL-LIKE PROPERTIES by Nischal K. Padala Microglia are the resident immune cells of the CNS. In the healthy CNS, they express negligible levels of MHC II molecules as well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in iso...
متن کاملThe FVB Background Does Not Dramatically Alter the Dystrophic Phenotype of Mdx Mice
The mdx mouse is the most frequently used animal model for Duchenne muscular dystrophy (DMD), a fatal muscle disease caused by the loss of dystrophin. Mdx mice are naturally occurring dystrophin-null mice on the C57BL/10 (BL10) background. We crossed black mdx to the white FVB background and generated mdx/FVB mice. Compared to that of age- and sex-matched FVB mice, mdx/FVB mice showed character...
متن کاملCadherin point mutations alter cell sorting and modulate GTPase signaling.
This study investigated the impact of cadherin binding differences on both cell sorting and GTPase activation. The use of N-terminal domain point mutants of Xenopus C-cadherin enabled us to quantify binding differences and determine their effects on cadherin-dependent functions without any potential complications arising as a result of differences in cytodomain interactions. Dynamic cell-cell b...
متن کاملPatey Prize 2 O8 Characterisation of Pancreatic Stellate Cell (psc) Exosomes and Their Impact on Pancreatic Cancer Cell Phenotype
O8 CHARACTERISATION OF PANCREATIC STELLATE CELL (PSC) EXOSOMES AND THEIR IMPACT ON PANCREATIC CANCER CELL PHENOTYPE SM Robinson (1,2), DA Mann (1), J Mann (1), RM Charnley (2), SA White (1,2) (1) Institute of Cellular Medicine, Newcastle University (2) Freeman Hospital, Newcastle upon Tyne Introduction: Background Exosomes vesicles measuring up to 100nm in size and play key roles in cellto-cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.lb611